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Tocris Bioscience™ SB 431542, Tocris Bioscience™

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Overview
956.00 GBP valid until 2025-07-30
Use promo code "24078" to get your promotional price.

Additional Details:
Additional Details: Weight: 0.00970kg



Product Code. 18064922

Quantity Price
1 £ 1195.0 / 50mg
In stock, ready to ship: 4
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Description and Specification

Specification

Chemical Name or Material SB 431542
CAS 301836-41-9
Synonym 4-5-benzo 1,3 dioxol-5-yl-4-pyridin-2-yl-1 h-imidazol-2-yl-benzamide;4-4-2 h-1,3-benzodioxol-5-yl-5-pyridin-2-yl-1 h-imidazol-2-yl benzamide
Quantity 50 mg
Molecular Formula C22H16N4O3
Formula Weight 384.39

SB 431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor/ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines.

SB 431542 synthesized to cGMP guidelines also available.

For more information about how SB 431542 may be used, see our protocols: 3D Culture of Lung Alveolar Cells, Differentiation of Hematopoietic Progenitors from hPSCs, Generating Midbrain Dopaminergic Neurons from hPSCs, Generating Vascular Organoids, Accelerated Induction of Cortical Neurons from hiPSCs .

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